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Search Results for " diabetes mellitus "

20

Compounds

Cat No. Product Name Synonyms Targets
T2701 GSK1292263 GPR
GSK1292263 is a GPR119 agonist and has been investigated for the treatment of DIABETES MELLITUS, TYPE 2.
TN1788 Isookanin Amylase
Isookanin shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with the IC50 value of 7.9 ± 0.53 μM. Isookanin is a potent inhibitor of α-amylase (IC50=0.447 mg/ml).
T9022 AZD9977 AZD 9977 Glucocorticoid Receptor
AZD9977 is a novel, selective modulator of mineralocorticoid receptor .
T0247 Acarbose BAY g 5421 Glucosidase
Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.
T2711 Chembridge-5861528 TCS 5861528 TRP/TRPV Channel
Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
T23521 VULM 1457 Acyltransferase
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of...
T1088 Repaglinide AG-EE 388 ZW,AG-EE 623ZW Potassium Channel , PPAR
Repaglinide (AG-EE 623ZW) is a benzoic acid derivative that stimulates insulin secretion from the pancreas and is used in the therapy of type 2 diabetes. Repaglinide has been linked to rare instances of clinically appare...
T8780 AMG131 INT-131,AMG-131,CHS 131 PPAR
AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin depende...
T0334 Rosiglitazone BRL49653 Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
T1603 Glipizide CP 28720,K 4024 Potassium Channel , PPAR , ABC
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T7369L Gemigliptin Tartrate(911637-19-9 free base) LC15-0444 tartrate Proteasome , DPP-4
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibit...
T6646 Rosiglitazone hydrochloride BRL-49653 HCl,Rosiglitazone HCl Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T1637 Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i...
T3104 Globalagliatin LY2608204 Glucokinase
Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.
T2316 Omarigliptin MK-3102 Proteasome , DPP-4
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency.
T71394 BMS-823778
BMS-823778 is an orally available potent and selective inhibitor of 11-β-hydroxysteroid-dehydrogenase 1 (11βHSD-1). BMS-823778 is a potential therapeutic agent for type 2 diabetes mellitus (T2DM).
T0490 Chlorpropamide Diabinese ATPase , ABC
Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
T6961 PX-478 PX-478 2HCl HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...
T2385 Ipragliflozin ASP1941 SGLT
Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.
TP1796 Albiglutide TFA (782500-75-8 free base) Albiglutide TFA Glucagon Receptor
Albiglutide TFA (782500-75-8 free base) (Albiglutide TFA) is a long acting GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus (T2DM).

Compounds

GSK1292263
T2701
Synonym:
Target: GPR
Isookanin
TN1788
Synonym:
Target: Amylase
AZD9977
T9022
Synonym: AZD 9977
Target: Glucocorticoid Receptor
Acarbose
T0247
Synonym: BAY g 5421
Target: Glucosidase
Chembridge-5861528
T2711
Synonym: TCS 5861528
Target: TRP/TRPV Channel
VULM 1457
T23521
Synonym:
Target: Acyltransferase
Repaglinide
T1088
Synonym: AG-EE 388 ZW,AG-EE 623ZW
Target: Potassium Channel, PPAR
AMG131
T8780
Synonym: INT-131,AMG-131,CHS 131
Target: PPAR
Rosiglitazone
T0334
Synonym: BRL49653
Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy
Glipizide
T1603
Synonym: CP 28720,K 4024
Target: Potassium Channel, PPAR, ABC
Gemigliptin Tartrate(911637-19-9 free base)
T7369L
Synonym: LC15-0444 tartrate
Target: Proteasome, DPP-4
Rosiglitazone hydrochloride
T6646
Synonym: BRL-49653 HCl,Rosiglitazone HCl
Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy
Deferoxamine Mesylate
T1637
Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM
Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy
Globalagliatin
T3104
Synonym: LY2608204
Target: Glucokinase
Omarigliptin
T2316
Synonym: MK-3102
Target: Proteasome, DPP-4
BMS-823778
T71394
Synonym:
Target:
Chlorpropamide
T0490
Synonym: Diabinese
Target: ATPase, ABC
PX-478
T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
Ipragliflozin
T2385
Synonym: ASP1941
Target: SGLT
Albiglutide TFA (782500-75-8 free base)
TP1796
Synonym: Albiglutide TFA
Target: Glucagon Receptor
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TargetMol